One NF1 Mutation may Conceal Another

Even is better than odd: one fat may conceal another.

1 2 Christophe BEAULOYE , Sandrine HORMAN & Luc BERTRAND 3 4 Université catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Pole of 5 Cardiovascular Research, Brussels, Belgium; Cliniques Universitaires Saint-Luc, Division of 6 Cardiology, Brussels, Belgium 7 8 9 Address for correspondence: Luc Bertrand 10 Pole of Cardiovascular Research 11 Institut de Recherche Expérimental...

A novel neurofibromatosis type 1 (NF1) mutation in a patient with NF1 and pheochromocytoma

Give Me Another One!

We investigate the complexity of an optimization problem in Boolean propositional logic related to information theory: Given a conjunctive formula over a set of relations, find a satisfying assignment with minimal Hamming distance to a given assignment that satisfies the formula (NearestOtherSolution, NOSol). We present a complete classification with respect to the relations admitted in the for...

Treatment with ivermectin: what works in one community may not work in another.

Nigeria is highly endemic for onchocerciasis, and seven million people are infected, 40 million at risk of infection and 0.2 million blind from the disease. Disease control is through mass distribution of ivermectin (Mectizan) “ a drug that has revolutionized the treatment of onchocerciasis and other nematode diseases of man”. What is needed therefore, is to put in place an eVective system of d...

One thing leads to another.

In 1956, the JCI published an article by Vincent Dole on a method for titrating plasma fatty acids that uncovered the importance of fatty acids as a substrate for glucose metabolism. When asked to prepare a historical perspective on this very popular paper, I paid Dole a visit and we reminisced. His answer to my question of how he came to do this work on plasma fatty acids was: "Well, one thing...